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1

Discovery of Selective Irreversible Inhibitors for Bruton’s Tyrosine Kinase

Zhengying Pan, Heleen Scheerens, Shyr-Jiann Li, Brian E. Schultz, Paul A. Sprengeler, L. Chuck Burrill, Rohan V. Mendonca, Michael D. Sweeney, Keana C. K. Scott, Paul G. Grothaus, Douglas A. Jeffery,

Journal:

Year:

2007

Language:

english

File:

PDF, 242 KB

english, 2007

2

Characterization of chemokines and chemokine receptors in two murine models of inflammatory bowel disease: IL-10– / – mice and Rag-2– / – mice reconstituted with CD4+CD45RBhigh T cells

Heleen Scheerens, Edith Hessel, Rene de Waal-Malefyt, Michael W. Leach, Donna Rennick

Journal:

European Journal of Immunology

Year:

2001

Language:

english

File:

PDF, 141 KB

english, 2001

3

Regulation of postischemic liver injury following different durations of ischemia

Hines, Ian N., Hoffman, Jason M., Scheerens, Heleen, Day, Brian J., Harada, Hirohisa, Pavlick, Kevin P., Bharwani, Sulaiman, Wolf, Robert, Gao, Bifeng, Flores, Sonia, McCord, Joe M., Grisham, Matthew

Journal:

AJP Gastrointestinal and Liver Physiology

Year:

2003

Language:

english

File:

PDF, 643 KB

english, 2003

4

Lebrikizumab Treatment in Adults with Asthma

Corren, Jonathan, Lemanske, Robert F., Hanania, Nicola A., Korenblat, Phillip E., Parsey, Merdad V., Arron, Joseph R., Harris, Jeffrey M., Scheerens, Heleen, Wu, Lawren C., Su, Zheng, Mosesova, Sofia,

Journal:

Boston Medical and Surgical Journal

Year:

2011

Language:

english

File:

PDF, 746 KB

english, 2011

5

Membrane-Bound TNF Supports Secondary Lymphoid Organ Structure but Is Subservient to Secreted TNF in Driving Autoimmune Inflammation

Sigrid R Ruuls, Robert M Hoek, Vu N Ngo, Tom McNeil, Linda A Lucian, Mary J Janatpour, Heinrich Körner, Heleen Scheerens, Edith M Hessel, Jason G Cyster, Leslie M McEvoy, Jonathon D Sedgwick

Journal:

Year:

2001

Language:

english

File:

PDF, 727 KB

english, 2001

6

Elevated IgE M1 prime transcripts in nasal tissues in patients with nasal polyps and asthma

Scheerens, Heleen, Smith, Ashley, Li, Olga, Honigberg, Lee, Harris, Jeffrey M., Holtappels, Gabriele, Bachert, Claus

Journal:

Journal of Allergy and Clinical Immunology

Year:

2018

Language:

english

File:

PDF, 242 KB

english, 2018

7

A randomized trial of the efficacy and safety of quilizumab in adults with inadequately controlled allergic asthma

Harris, Jeffrey M., Maciuca, Romeo, Bradley, Mary S., Cabanski, Christopher R., Scheerens, Heleen, Lim, Jeremy, Cai, Fang, Kishnani, Mona, Liao, X. Charlene, Samineni, Divya, Zhu, Rui, Cochran, Colett

Journal:

Respiratory Research

Year:

2016

Language:

english

File:

PDF, 1.53 MB

english, 2016

8

Increased IgE + B Cells in Sputum, but Not Blood, Bone Marrow, or Tonsils, after Inhaled Allergen Challenge in Subjects with Asthma

Oliveria, John-Paul, Salter, Brittany M., MacLean, Jonathan, Kotwal, Shweta, Smith, Ashley, Harris, Jeffrey M., Scheerens, Heleen, Sehmi, Roma, Gauvreau, Gail M.

Journal:

American Journal of Respiratory and Critical Care Medicine

Year:

2017

Language:

english

File:

PDF, 590 KB

english, 2017

9

Long-term Topical Exposure to Toluene Diisocyanate in Mice Leads to Antibody Production and In Vivo Airway Hyperresponsiveness Three Hours after Intranasal Challenge

SCHEERENS, HELEEN, BUCKLEY, THERESA L., MUIS, THEA LEUSINK, GARSSEN, JOHAN, DORMANS, JAN, NIJKAMP, FRANS P., VAN LOVEREN, HENK

Journal:

American Journal of Respiratory and Critical Care Medicine

Year:

1999

Language:

english

File:

PDF, 92 KB

english, 1999

10

[American Thoracic Society American Thoracic Society 2012 International Conference, May 18-23, 2012 â¢ San Francisco, California - ()] C32. REFRACTORY ASTHMA - Immunophenotyping Of Peripheral Blood Lymphocyte Subsets In Severe Asthmatics

Bremer, Meire, Scheerens, Heleen, Harris, Jeffrey M., Arron, Joseph R.

Year:

2012

File:

PDF, 17 KB

2012

11

The involvement of sensory neuropeptides in toluene diisocyanate-induced tracheal hyperreactivity in the mouse airways

Heleen Scheerens, Theresa L. Buckley, Thea Muis, Henk Van Loveren, Frans P. Nijkamp

Journal:

British Journal of Pharmacology

Year:

1996

Language:

english

File:

PDF, 1.45 MB

english, 1996

12

Oxygen and Xenobiotic Reductase Activities of Cytochrome P450

Goeptar, Arnold R., Scheerens, Heleen, Vermeulen, Nico P. E.

Journal:

Critical Reviews in Toxicology

Year:

1995

Language:

english

File:

PDF, 3.64 MB

english, 1995

13

Targeting IgE production in mice and humans

Wu, Lawren C, Scheerens, Heleen

Journal:

Current Opinion in Immunology

Year:

2014

Language:

english

File:

PDF, 1.02 MB

english, 2014

14

Bioanalytical challenges and improved detection of circulating levels of IL-13

Cai, Fang, Hornauer, Hans, Peng, Kun, Schofield, Cheryl A, Scheerens, Heleen, Morimoto, Alyssa M

Journal:

Year:

2016

Language:

english

File:

PDF, 1.04 MB

english, 2016

15

The Extent of Serum Periostin Reduction in Asthma Patients Treated with Lebrikizumab Is Related to Baseline Periostin Levels: A Pooled Analysis of Phase II Studies

Choy, David F., Holweg, Cecile T.J., Cai, Fang, Arron, Joseph R., Matthews, John G., Scheerens, Heleen

Journal:

Journal of Allergy and Clinical Immunology

Year:

2016

Language:

english

File:

PDF, 125 KB

english, 2016

16

[American Thoracic Society American Thoracic Society 2012 International Conference, May 18-23, 2012 â¢ San Francisco, California - ()] B37. NEW INSIGHTS INTO ASTHMA AND COPD TREATMENT - Effect Of An Anti-M1 Prime Monoclonal Antibody, MEMP1972A, In A Phase II Proof-Of-Activity Allergen Challenge Study In Patients With Mild Asthma

Gauvreau, Gail, Boulet, Louis-Philippe, Cockcroft, Donald W., Davis, Beth, Fitzgerald, Mark J., Leigh, Richard, Dahlen, Barbro, Mayers, Irvin, Scheerens, Heleen, Maciuca, Romeo, Matthews, John G., Har

Year:

2012

File:

PDF, 19 KB

2012

17

Clinical Pharmacology of an Anti-CD4 Monoclonal Antibody with Enhanced FcRn Binding Affinity in a Phase I Study for Rheumatoid Arthritis

Heleen Scheerens, Yanan Zheng, John Davis, Zheng Su, Rong Deng, Sally Fischer, Cynthia Woods, Paul Fielder, Eric Stefanich

Journal:

Clinical Immunology

Year:

2010

Language:

english

File:

PDF, 44 KB

english, 2010

18

[American Thoracic Society American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California - ()] B33. ASTHMA THERAPY: NOVEL APPROACHES - Treatment With MEMP1972A, An Anti-M1 Prime Monoclonal Antibody, Reduced Serum IgE In Healthy Volunteers And Patients With Allergic Rhinitis

Scheerens, Heleen, Putnam, Wendy, Zheng, Yanan, Wang, Yehong, Mosesova, Sofia, Maciuca, Romeo, Liao, X C., Wu, Lawren C., Matthews, John G., Harris, Jeffrey M.

Year:

2012

Language:

english

File:

PDF, 18 KB

english, 2012

19

Dose-ranging study of lebrikizumab in asthmatic patients not receiving inhaled steroids

Noonan, Michael, Korenblat, Phillip, Mosesova, Sofia, Scheerens, Heleen, Arron, Joseph R., Zheng, Yanan, Putnam, Wendy S., Parsey, Merdad V., Bohen, Sean P., Matthews, John G.

Journal:

Journal of Allergy and Clinical Immunology

Year:

2013

Language:

english

File:

PDF, 1.88 MB

english, 2013

20

Lebrikizumab in moderate-to-severe asthma: pooled data from two randomised placebo-controlled studies

Hanania, Nicola A, Noonan, Michael, Corren, Jonathan, Korenblat, Phillip, Zheng, Yanan, Fischer, Saloumeh K, Cheu, Melissa, Putnam, Wendy S, Murray, Elaine, Scheerens, Heleen, Holweg, Cecile TJ, Maciu

Journal:

Year:

2015

Language:

english

File:

PDF, 1.18 MB

english, 2015

21

A randomized trial of quilizumab in adults with refractory chronic spontaneous urticaria

Harris, Jeffrey M., Cabanski, Christopher R., Scheerens, Heleen, Samineni, Divya, Bradley, Mary S., Cochran, Colette, Staubach, Petra, Metz, Martin, Sussman, Gordon, Maurer, Marcus

Journal:

Journal of Allergy and Clinical Immunology

Year:

2016

Language:

english

File:

PDF, 949 KB

english, 2016

22

Efficacy and Safety of Lebrikizumab in Severe Uncontrolled Asthma: Results from the Lute and Verse Phase II Randomized, Double-Blind, Placebo-Controlled Trials

Hanania, Nicola A., Noonan, Michael J., Corren, Jonathan, Korenblat, Phillip, Zheng, Yanan, Putnam, Wendy, Murray, Elaine, Abelardo, Connie, Scheerens, Heleen, Maciuca, Romeo, Gray, Sarah, Doyle, Ramo

Journal:

Journal of Allergy and Clinical Immunology

Year:

2014

Language:

english

File:

PDF, 40 KB

english, 2014

23

[American Thoracic Society American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California - ()] C22. ASTHMA THERAPY - Lebrikizumab Treatment Reduces Serum Periostin Levels In Asthma Patients With Elevated Baseline Levels Of Periostin

Scheerens, Heleen, Arron, Joseph R., Choy, David F., Mosesova, Sofia, Lal, Preeti, Matthews, John G.

Year:

2012

Language:

english

File:

PDF, 19 KB

english, 2012

24

Novel, potent, selective, and orally bioavailable human βII-tryptase inhibitors

David Sperandio, Vincent W.-F. Tai, Julia Lohman, Bernie Hirschbein, Rohan Mendonca, Chang-Sun Lee, Jeffrey R. Spencer, James Janc, Margaret Nguyen, Jerlyn Beltman, Paul Sprengeler, Heleen Scheerens,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 161 KB

english, 2006

25

Accelerated alveolar bone loss in mice lacking interleukin-10: late onset

Abdulaziz Al-Rasheed, Heleen Scheerens, Apurva K. Srivastava, Donna M. Rennick, Dimitris N. Tatakis

Journal:

Journal of Periodontal Research

Year:

2004

Language:

english

File:

PDF, 100 KB

english, 2004

26

Noninvasive Biomarkers That Predict Treatment Benefit from Biologic Therapies in Asthma

Arron, Joseph R., Choy, David F., Scheerens, Heleen, Matthews, John G.

Journal:

Annals of the American Thoracic Society

Year:

2013

Language:

english

File:

PDF, 777 KB

english, 2013

27

MTRX1011A, a humanized anti-CD4 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: a Phase I randomized, double-blind, placebo-controlled study incorporating pharmacodynamic biomarker assessments

Scheerens, Heleen, Su, Zheng, Irving, Bryan, Townsend, Michael J, Zheng, Yanan, Stefanich, Eric, Chindalore, Vishala, Bingham, Clifton O, Davis, John C

Journal:

Arthritis Research & Therapy

Year:

2011

Language:

english

File:

PDF, 260 KB

english, 2011

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